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Mien-Chie Hung Cancer Gene Therapy by Viral and Non-viral Vectors


Provides expert, state-of-the-art insight into the current progress of viral and non-viral gene therapy Translational medicine has opened the gateway to the era of personalized or precision medicine. No longer a one-size-fits-all approach, the treatment of cancer is now based on an understanding of underlying biologic mechanisms and is increasingly being tailored to the molecular specificity of a tumor. This book provides a comprehensive overview of the pertinent molecular discoveries in the cancer field and explains how these are being used for gene-based cancer therapies. Designed as a volume in the Translational Oncology book series, Cancer Gene Therapy by Viral and Non-viral Vectors deals with the practice of gene-therapy, with reference to vectors for gene expression and gene transfer, as well as viral therapy. It covers the history and current and future applications of gene transfer in cancer, and provides expert insight on the progress of viral and non-viral gene therapy with regard to delivery system, vector design, potential therapeutic genes, and principles and regulations for cancer gene therapy. Presented in three parts, Cancer Gene Therapy by Viral and Non-viral Vectors covers: Delivery Systems • Translational Cancer Research: Gene Therapy by Viral and Non-viral Vectors • Retroviruses for Cancer Therapy • DNA Plasmids for Non-viral Gene Therapy of Cancer • Cancer Therapy with RNAi delivered by Non-viral Membrane/Core Nanoparticles Targeted Expression • Cancer Gene Therapy by Tissue-specific and Cancer-targeting Promptors • MicroRNAs as Drugs and Drug Targets in Cancer Principles of Clinical Trials in Gene Therapy • Regulatory issues for Manufacturers of Viral Vectors and Vector-transduced Cells for Phase I/II Trials • US Regulations Governing Clinical Trials in Gene Therapy • Remaining Obstacles to the Success of Cancer Gene Therapy Focusing on speeding the process in clinical cancer care by bringing therapies as quickly as possible from bench to bedside, Cancer Gene Therapy by Viral and Non-viral Vectors is an absolutely vital book for physicians, clinicians, researchers, and students involved in this area of medicine.

11531.5 РУБ

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Martin Schleef Minicircle and Miniplasmid DNA Vectors. The Future of Non-viral Viral Gene Transfer


This first title on the topic provides complete coverage, including the molecular basis, production and possible biomedical applications. Written by the most prominent academic researchers in the field as well as by researchers at one of the worlds leading companies in industrial production of minicircle DNA, this practical book is aimed at everyone who is directly or indirectly involved in the development of gene therapies.

11162.94 РУБ

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Pathak Yashwant Antibody-Mediated Drug Delivery Systems. Concepts, Technology, and Applications


This book covers various aspects of antibody mediated drug delivery systems – theoretical aspects, processing, viral and non-viral vectors, and fields where these systems find and /or are being evaluated for applications as therapeutics and diagnostic treatment. Chapters discuss actual applications of techniques used for formulation and characterization. Applications areas include cancer, pulmonary, ocular diseases; brain drug delivery; and vaccine delivery. The contributing authors represent over 10 different countries, covering recent developments happening around the globe.

12436.29 РУБ

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Jeang Kuan-Teh Viral Oncology. Basic Science and Clinical Applications


A comprehensive look at the latest research findings and clinical applications of oncogenic viruses Written by a panel of academic experts, Viral Oncology is the first self-contained and comprehensive book to present both scientific and clinical information on viruses linked to some of the most important human cancers. Readers can turn to this book for the most in-depth and up-to-date coverage of: HPV-associated cancers; molecular events associated with HPV-induced human cancer; the role of the HPV E6 oncoprotein in malignant progression; virus association with brain tumors; involvement of the polyomavirus JCV in colorectal cancer; possibleassociation of BKV with prostate cancer; oncogenic transformation bypolyomavirus large T antigen; SV40 and human cancer; SV40 and mesothelioma; molecular immunology of hepatitis B–associated viral cancer; hepatitis B vaccine and hepatocellular carcinoma; pathogenesis of acute and chronic hepatitis Cvirus infection; molecular mechanisms of hepatitis C virus-induced cellulartransformation; clinical aspects of HTLV-1 associated cancer; oncogenic potential of the HTLV-1 tax protein; HIV-associated malignancy; HIV-related lymphoma; biology and epidemiology of HHV-8; the role of KSHV in pathogenesis of Kaposissarcoma; molecular pathobiology of EBV infection; and EBV as a pathogen. Several chapters are devoted to the basic science of oncogenic viruses for thestudy of their pathogenesis, drug development, and employment of viral vectorsfor vaccine and gene therapy. The book also includes complementary clinically based chapters describing natural courses and treatments. Additionally, bonusclinical materials are embedded within chapters and an easy-to-use indexcompletes the book. Viral Oncology is an essential resource for clinical and research oncologists in medical facilities and biological research laboratories; clinicians and scientists working in related biomedical areas; medical students working toward a first or higher degree in the life sciences and other biomedical fields; and pharmaceutical scientists and developers.

14396.55 РУБ

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Sven Wilde Viral Marketing within Social Networking Sites. The creation of an effective Campaign


Primarily, a review on theoretical foundations and the history of Viral Marketing is shown. Based on this, different definitions were analysed to set up a practical definition for this study. Thereafter, possible targets of Viral Marketing are illustrated, followed by necessary elements of Viral Marketing campaigns and finally by an approach to measure the effectiveness. By means of an online questionnaire, a survey was conducted to collect empirical data. These data provide information about Viral Marketing within social networking sites and detect useful information for the practical use of Viral Marketing. The results of the analysis show the accelerating influence of social networking sites and other factors regarding the effectiveness of Viral Marketing. In addition, specific characteristics which make Viral Marketing messages appealing as well as the preferred types of Viral Marketing messages are illustrated. They help to understand how to create and design an effective Viral Marketing Campaign.

6739 РУБ

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Maria Petrescu Viral Marketing and Social Networks


Viral marketing is the key to marketing successin the 21st century, and advertising is one ofthe most important tools in the viral marketingtoolkit. This book offers an in-depth look at viralmarketing that includes a short overview of itshistory and evolution.The author provides a viral marketingtoolkit-exploring the use of each tool in socialmedia, as well as differences between connectedterms such as marketing buzz. Viral advertising,as a significant tool and source of viral message,is discussed in detail with examples ofvarious companies' viral campaigns. The focusis on how and where businesses can post messageswith viral objectives and which consumersegment is the center of the initial targetinginitiative.This book is for anyone-students and professorsin business and communication schools, aswell as marketing practitioners.

4539 РУБ

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Sven Wilde Viral Marketing within Social Networking Sites


Master's Thesis from the year 2012 in the subject Communications - Public Relations, Advertising, Marketing, Social Media, grade: 1,3, University of Siegen (Fakultät III), language: English, abstract: Primarily, a review on theoretical foundations and the history of Viral Marketing is shown. Based on this a variety of different definitions were analysed to set up a practical definition for this thesis. Thereafter, possible targets of Viral Marketing are illustrated, followed by necessary elements of Viral Marketing campaigns, and finally by an approach to measure the effectiveness. By means of an online questionnaire, a survey was conducted to collect empirical data from which to analyse Viral Marketing within social networking sites and detect useful information for the practical use of Viral Marketing. The results of the analysis show the accelerating influence of social networking sites and other factors regarding the effectiveness of Viral Marketing. In addition, specific characteristics which make Viral Marketing messages appealing, as well as the preferred types of Viral Marketing messages are illustrated and should help to understand how to create and design an effective Viral Marketing Campaign.

6052 РУБ

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Christon Hurst J. Studies in Viral Ecology. Animal Host Systems


This book explains the ecology of viruses by examining their interactive dynamics with their hosting species (in this volume, in animals), including the types of transmission cycles that viruses have evolved encompassing principal and alternate hosts, vehicles and vectoring species. Examining virology from an organismal biology approach and focusing on the concept that viral infections represent areas of overlap in the ecologies of the involved species, Viral Ecology is essential for students and professionals who either may be non-virologists or virologists whose previous familiarity has been very specialized.

12436.29 РУБ

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Thyagarajan Bhaskar Primary and Stem Cells. Gene Transfer Technologies Applications


This book describes basic cell engineering methods, emphasizing stem cell applications, and use of the genetically modified stem cells in cell therapy and drug discovery. Together, the chapters introduce and offer insights on new techniques for engineering of stem cells and the delivery of transgenes into stem cells via various viral and non-viral systems. The book offers a guide to the types of manipulations currently available to create genetically engineered stem cells that suit any investigators purpose, whether its basic science investigation, creation of disease models and screens, or cells for therapeutic applications.

9575.08 РУБ

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Uversky Vladimir Flexible Viruses. Structural Disorder in Viral Proteins


This book provides up-to-date information on experimental and computational characterization of the structural and functional properties of viral proteins, which are widely involved in regulatory and signaling processes. With chapters by leading research groups, it features current information on the structural and functional roles of intrinsic disorders in viral proteomes. It systematically addresses the measles, HIV, influenza, potato virus, forest virus, bovine virus, hepatitis, and rotavirus as well as viral genomics. After analyzing the unique features of each class of viral proteins, future directions for research and disease management are presented.

12888.66 РУБ

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Christon Hurst J. Studies in Viral Ecology. Microbial and Botanical Host Systems


This book explains the ecology of viruses by examining their interactive dynamics with their hosting species (in this volume, in microbes and plants), including the types of transmission cycles that viruses have evolved encompassing principal and alternate hosts, vehicles, and vectoring species. Examining virology from an organismal biology approach and focusing on the concept that viral infections represent areas of overlap in the ecologies of the involved species, Viral Ecology is essential for students and professionals who either may be non-virologists or virologists whose previous familiarity has been very specialized.

12275.7 РУБ

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Anne Bridgen Reverse Genetics of RNA Viruses. Applications and Perspectives


Reverse genetics, the genetic manipulation of RNA viruses to create a wild-type or modified virus, has led to important advances in our understanding of viral gene function and interaction with host cells. Since many severe viral human and animal pathogens are RNA viruses, including those responsible for polio, measles, rotaviral diarrhoea and influenza infections, it is also an extremely powerful technique with important potential application for the prevention and control of a range of human and animal viral diseases. Reverse Genetics of RNA Viruses provides a comprehensive account of the very latest developments in reverse genetics of RNA viruses through a wide range of applications within each of the core virus groups including; positive sense, negative sense and double stranded RNA viruses. Written by a team of international experts in the field, it provides a unique insight into how the field has developed, what problems are being addressed now and where applications may lead in the future. It will prove invaluable to bioscience, medical and veterinary students, those starting research in this area as well as other researchers and teachers needing to update their knowledge of this fast-moving field. An authoritative, comprehensive overview of reverse genetics in RNA Viruses. Includes numerous examples of cutting- edge applications of reverse genetics within each of the RNA viral groups. Written by a team of international experts, including some of the leading researchers in the field.

12275.7 РУБ

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Christon Hurst J. Studies in Viral Ecology. Microbial and Botanical Host Systems


This book explains the ecology of viruses by examining their interactive dynamics with their hosting species (in this volume, in microbes and plants), including the types of transmission cycles that viruses have evolved encompassing principal and alternate hosts, vehicles, and vectoring species. Examining virology from an organismal biology approach and focusing on the concept that viral infections represent areas of overlap in the ecologies of the involved species, Viral Ecology is essential for students and professionals who either may be non-virologists or virologists whose previous familiarity has been very specialized.

12436.29 РУБ

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Bernard Naafs Imported Skin Diseases


Global movement of people leads to the global movement of disease International travel enables skin diseases to move around the world with increasing ease. Skin diseases transmitted through casual contact with people, animal vectors and a foreign environment are particularly prone to transport. Dermatologists need to recognize the signs and symptoms of disease not native to their environment to enable proper diagnosis and care. Imported Skin Diseases provides a clinical guide to the foreign diseases increasingly seen in ‘Western’ clinics. With a focus on accurate diagnosis and effective therapy, the book covers: Differences between pigmented and non-pigmented skin Viral, bacterial and fungal Infections Parasitic infestations Sexually transmitted diseases Aquatic diseases Written by an international team of experts, with practical tips throughout, Imported Skin Diseases prepares you for the unusual skin diseases you are increasingly likely to see in your clinic.

12275.7 РУБ

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Foster Graham Clinical Dilemmas in Viral Liver Disease


Clinical Dilemmas in Viral Liver Disease is a practical up-to-date handbook providing answers to the questions and challenges that arise in day-to-day practice. Each short chapter addresses a different topic and provides evidence-based guidance on subjects ranging from optimizing current management through to special management problems and novel treatments. This book is suitable for all medical professionals involved in the care of patients with viral liver disease: established and trainee hepatologists, pediatric hepatologists, pathologists, radiologists, transplant surgeons and nurse specialists

8289.61 РУБ

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This booklet introduces Dr. Max Gerson and the foundation of the Gerson Therapy, that cancer and most chronic diseases are able to manifest in the body because of toxicity and nutritional deficiency. Charlotte Gerson gives an overview of the Gerson Therapy and reviews some of the methods used in the program, with a focus on Prostate and Testicular cancer. Also included are factual case histories of individuals confronted with either Prostate or Testicular cancer and how they overcame it using the Gerson Therapy.

889 РУБ

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Hugo Kubinyi Chemokine Receptors as Drug Targets


Chemokines are hormone-like signaling molecules secreted by cells to signal infection and guide the immune response. Following a decade of basic chemokine research, the pharmaceutical industry has now begun to exploit this crucial signaling pathway for the development of innovative drugs against AIDS, cancer, neural and autoimmune diseases. Here is the first reference focusing on these novel drug development opportunities. Opening with a general introduction on chemokine function and chemokine receptor biology, the second part covers the known implications of these signaling molecules in human diseases, such as cancer, neural disorders, and viral infection, including AIDS. The third part systematically surveys current drug development efforts at targeting individual chemokine receptors, as well as other chemokine interaction partners, including up-to-date reports from the pharmaceutical industry.

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Ralf Bruser Viral Marketing in Social Media. Planung, Seeding Und Steuerung


Das Web 2.0 stellt Marketing-Verantwortliche vor neue Herausforderungen, bietet aber auch neue Mittel und Wege ihre Kunden zu erreichen und somit eine hohe Markenbekanntheit und ein unverwechselbares Markenimage zu kreieren.Die vorliegende Studie erläutert zunächst das Kommunikationsverhalten im Web 2.0 und widmet sich anschließend dem Viral Marketing als Weiterentwicklung der Mund-zu-Mund-Propaganda. Das Übertragungsumfeld wird mit Hilfe soziologischer, sozialpsychologischer und netzwerktheoretischer Erkenntnisse untersucht und die Wirkungsweisen und Potenziale sozialer Bindungen sowie die Netzwerkstruktur von virtuellen sozialen Netzwerken werden analysiert. Gefolgt wird die Analyse der Makro-Variablen von der Analyse der Mikro-Variablen. Diese liefern ein Verständnis für individuelle Motive zur Weitergabe von (Marketing-) Botschaften. Die gesammelten Erkenntnisse werden im Rahmen der Diffusion von Viral Marketing in Social Media Plattformen analysiert und diskutiert. Aus dieser Analyse wird ein Viral Marketing Prozess auf Social Media Plattformen abgeleitet, welcher der strategischen Planung, dem Seeding und der Steuerung von Viral Marketing Kampagnen in Social Media Applikationen dienlich sein soll. Im Rahmen der theoretischen Abhandlung werden final alle Ergebnisse zusammengefasst, reflektiert und offene Problemstellungen diskutiert. Diese werden schließlich einer empirischen Untersuchung unterzogen, um relevante und empirisch fundierte Lösungsansätze zu erarbeiten.

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